2. Natural Products
  3. Antibiotics
  4. Beta-lactam Antibiotics

Beta-lactam Antibiotics

β-lactam antibiotics are characterized by four-membered ß-lactam ring. Penicillin G was the first β-lactam antibiotic that entered the clinic. Almost all ß-lactam antibiotics derived initially from microbes through a fermentation process. β-lactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The activity of these antibiotics is related to the opening of the ß-lactam ring. These antibiotics have broad antibacterial spectrum, strong antibacterial activity, low toxicity, high industrial level, clear structure-activity relationship, and high alterability, so they have been widely developed and applied.

Beta-lactam Antibiotics (25):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-13678
    Meropenem 96036-03-2 99.85%
    Meropenem (SM 7338) is a carbapenem antibiotic with broad-spectrum antibacterial activity. Meropenem has activity against susceptible and resistant N. gonorrhoeae (MIC value of 0.02-0.06 mg/mL), H. influenzae (MIC value of 0.03-0.12 mg/mL), and H. ducreyi (MIC value of 0.015-0.12 mg/mL).
    Meropenem
  • HY-B1418
    Tazobactam 89786-04-9 99.94%
    Tazobactam (CL-298741) is a potent β-lactamases inhibitor and penicillin antibiotic. Tazobactam has antibacterial activity. Tazobactam can be used for pneumonia research.
    Tazobactam
  • HY-B1463
    Penicillin G sodium salt 69-57-8 98.06%
    Penicillin G sodium salt is a typical β-lactam antibiotic.
    Penicillin G sodium salt
  • HY-B0975
    Penicillin V Potassium 132-98-9 99.01%
    Penicillin V Potassium (Phenoxymethylpenicillin potassium salt) is an orally active antibiotic. Penicillin V Potassium inhibits the growth of Streptococci, C. difficile and S. aureus. Penicillin V Potassium can be used for the research of otitis, sinusitis, pharyngitis and tonsillitis.
    Penicillin V Potassium
  • HY-B1463R
    Penicillin G sodium salt (Standard) 69-57-8
    Penicillin G sodium salt (Standard) is the analytical standard of Penicillin G sodium salt. This product is intended for research and analytical applications. Penicillin G sodium salt is a typical β-lactam antibiotic.
    Penicillin G sodium salt (Standard)
  • HY-N11247
    Agrocin 84 59111-78-3
    Agrocin 84 is a microbial metabolite that inhibits DNA and protein synthesis and amino acid transport in a susceptible, virulent strain of A. tumefaciens H-38-9.
    Agrocin 84
  • HY-N14226
    Eurystatin B 137563-64-5
    Eurystatin B is a prolyl endopeptidase (PED) inhibitor. Eurystatin B has a protective effect during Scopolamine (HY-N0296)-induced amnesia in rats.
    Eurystatin B
  • HY-N5204
    Clavalanine 74758-63-7
    Clavalanine (Ro 22-5417) inhibits a variety of bacteria and fungi.
    Clavalanine
  • HY-122955
    Xanthobaccin A 227596-81-8
    Xanthobaccin A is an antifungal compound, can be isolated from the culture fluid of Stenotrophomonas sp. strain SB-K88. Xanthobaccin A has potent inhibitory effect on sugar beet damping-off disease.
    Xanthobaccin A
  • HY-B0975R
    Penicillin V Potassium (Standard) 132-98-9
    Penicillin V (Potassium) (Standard) is the analytical standard of Penicillin V (Potassium). This product is intended for research and analytical applications. Penicillin V Potassium (Phenoxymethylpenicillin potassium salt) is an orally active antibiotic. Penicillin V Potassium inhibits the growth of Streptococci, C. difficile and S. aureus. Penicillin V Potassium can be used for the research of otitis, sinusitis, pharyngitis and tonsillitis.
    Penicillin V Potassium (Standard)
  • HY-117108
    Nocardicin A 39391-39-4
    Nocardicin A is a beta-lactam antibiotic with selective antibacterial activity. Nocardicin A has moderate antibacterial activity against a broad spectrum of Gram-negative bacteria including Proteus and Pseudomonas; it has no inhibitory effect on Staphylococcus, Mycobacterium, fungi, and yeast.
    Nocardicin A
  • HY-B0030R
    D-Cycloserine (Standard) 68-41-7
    D-Cycloserine (Standard) is the analytical standard of D-Cycloserine. This product is intended for research and analytical applications. D-Cycloserine is an antibiotic which targets sequential bacterial cell wall peptidoglycan biosynthesis enzymes. D-Cycloserine is a partial NMDA agonist that can improve cognitive functions. D-Cycloserine can be used for multidrug-resistant tuberculosis research.
    D-Cycloserine (Standard)
  • HY-120572
    PI-091 129051-63-4
    PI-091 is a platelet aggregation inhibitor, and can be used for researching platelet aggregation.
    PI-091
  • HY-121120
    Isosulfazecin 77900-75-5
    Isosulfazecin (iSZ) is a novel β-lactam antibiotic produced by Pseudomonas acidophilus sp., synthesized in a nutrient solution supplemented with glycerol and sodium thiosulfate under aerobic conditions in parallel with bacterial growth. It is purified by chromatography and crystallization from aqueous methanol. Physicochemical analysis determined its molecular formula to be C12H20N4O9S, showing a structure with a β-lactam ring, methoxyl and sulfonate groups. Acid hydrolysis yields L-alanine and D-glutamic acid. iSZ is a diastereomer of sulfadiazine and exhibits moderate activity against both gram-positive and gram-negative bacteria, but potent activity against bacteria resistant to β-lactam antibiotics.
    Isosulfazecin
  • HY-B1418R
    Tazobactam (Standard) 89786-04-9
    Tazobactam (Standard) is the analytical standard of Tazobactam. This product is intended for research and analytical applications. Tazobactam (CL-298741) is a potent β-lactamases inhibitor and penicillin antibiotic. Tazobactam has antibacterial activity. Tazobactam can be used for pneumonia research.
    Tazobactam (Standard)
  • HY-N15020
    Izumenolide 76265-39-9
    Izumenolide is found in the strain of Micromonospora chalcea subsp. izumensis. Izumenolide inhibited some β-lactamases, and the IC50 concentration of TEM-2 β-lactamase was 0.01 μg/mL.
    Izumenolide
  • HY-N14007
    Cephamycin B 34279-77-1
    Cephalomycin B showes weak activity against Gram-positive and negative bacteria.
    Cephamycin B
  • HY-N13996
    Clavamycin B 103080-36-0
    Clavamycin B has strong anti-candida activity, and its action can be antagonized by dipeptide or tripeptide, but amino acid can not cancel its action. No antibacterial activity and no inhibition of β-lactamase.
    Clavamycin B
  • HY-N14005
    Cephamycin A 34279-78-2
    Cephalomycin A shows weak activity against Gram-positive and negative bacteria.
    Cephamycin A
  • HY-N14108
    Chlorocardicin 95927-71-2
    Chlorocardicin is a monocyclic beta-lactam. Chlorocardicin has moderate in vitro activity against Enterobacteriaceae and Pseudomonas aeruginosa.
    Chlorocardicin